MCAT MCQS PDF
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Strain P accumulates citrulline. This means that the synthetic pathway was working up to citrulline but then was blocked from progressing. This means that the next step in the production line, the gene product from argG, is not functional mutation.
Thus we have our answer. Going Deeper: Strain Q: no accumulation of citrulline means that there must be a blockage before that point, so given the information presented, argF must have a mutation meaning ornithine accumulates.
MDCAT 2018 full Paper PDF (with answer key)
Adding ornithine: no growth and it accumulates. Thus strain Q has must have 2 mutations in the synthesis pathway shown. Figure 1: Dialysis. The latter is liquid containing chemicals used to draw fluids and toxins out of the bloodstream and supply electrolytes and other chemicals to the bloodstream.
The membrane in the dialyzer separating the dialysate and the blood must be semipermeable. The concentration of toxins in the dialysate must increase during dialysis.
Excessive minerals and toxins cross the membrane in the dialyzer by osmosis. Submit answer Correct Answer: D Explanation On the Surface: Dialysis only refers to the transfer of the solute diffusion , while the transfer of the solvent is called osmosis.
Going Deeper: Diffusion is the movement of a substance down its concentration gradient from a region of high concentration to one of lower concentration. This is the process that must be occurring in the dialyser to remove toxins from the blood because the dialysate, logically, would have no toxins so the toxins defuse out of the blood into the dialysate. Osmosis is the movement of a solvent across a semi-permeable membrane from a region of low solute concentration to a region of high solute concentration.
In Biology and Biochemistry, that solvent is, of course, water. In this context, the easier way to imagine osmosis is that it is simply the diffusion of water across a semi-permeable membrane from a region of high water concentration i. So in summary, osmosis deals with how much water passes through the membrane, while dialysis deals with what type of solute i.
Notice the link between diffusion and osmosis and the Second Law of Thermodynamics Physics. All spontaneous change leads to an increase in the entropy randomness of the universe.
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This necessarily means that both P and Q have a functioning enzyme argininosuccinase see Figure 1. Muhammad Rahimi Bin Satar.